Epidermal Growth Factor/Transforming Growth Factor Alpha Receptors and Psoriasis
نویسندگان
چکیده
منابع مشابه
Modulation of epidermal growth factor receptors by human alpha interferon.
Treatment of Madin-Darby bovine kidney (MDBK) cells with human interferon (IFN)-alpha 2 at 37 degrees C results in a dose-dependent inhibition of cell growth and a reduction of the subsequent binding of 125I-labeled epidermal growth factor (EGF) at 4 degrees C. Human IFN-beta and -gamma, which exhibit little antiviral and antiproliferative activities on MDBK cells, have little effect on cell gr...
متن کاملEpidermal growth factor and transforming growth factor alpha.
This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth factors alpha (TGF alpha), the biosynthesis and tissue distribution of these molecules and a brief description of the effects of these molecules in culture and animals. An analysis of the similarities between the EGFs and TGF alpha s from different organisms is used to...
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The epidermal growth factor (EGF) receptor mediates the induction of a transformed phenotype in normal rat kidney (NRK) cells by transforming growth factors (TGFs). The ability of EGF and its analogue TGF-alpha to induce the transformed phenotype in NRK cells is greatly potentiated by TGF-beta, a polypeptide that does not interact directly with binding sites for EGF or TGF-alpha. Our evidence i...
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Growth factors are polypeptides that stimulate cell proliferation through binding to specific high-affinity cell membrane receptors. Plasma contains small quantities of growth factors. Platelets contain large amounts and it is thought that these are delivered to sites of injury where they may influence wound healing and repair. Growth factors are present in a variety of other tissues and have d...
متن کاملDimerization of internalized epidermal growth factor receptors.
Binding of epidermal growth factor (EGF) to cell surface EGF receptors initiates the formation of the receptor homodimers that can be detected by covalent cross-linking in intact cells or in detergent-solubilized cell extracts. Low pH dissociation of EGF from surface receptors results in immediate monomerization of receptor dimers. Using chemical cross-linking during mild permeabilization or ce...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1990
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12505661